Sustained Release Weight Support Capsules
Phentermine • Bupropion • Topiramate • Naltrexone • Methylcobalamin (B12)
Prescription only • Compounded in Florida • Telehealth Guided
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🌿 Comprehensive Multi Pathway Weight Support
MetaVance Rx™ is a precision compounded, sustained release capsule designed for individuals who struggle with appetite control, emotional eating, energy fluctuations, and metabolic imbalance.
Formulated in our licensed 503A compounding pharmacy in Florida, this capsule blends five active ingredients that work across multiple pathways to support steady, sustainable weight loss.
It’s an excellent option for patients who prefer a non injectable, non surgical approach to weight management.
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🔬 What’s Inside MetaVance Rx™
Ingredient Clinical Role
Phentermine Centrally acting stimulant that suppresses appetite and boosts energy. FDA approved for short term obesity treatment.
Bupropion HCl NDRI that supports mood regulation and reduces emotional eating.
Topiramate Enhances satiety and reduces compulsive eating behaviors. Often paired with phentermine for long term weight loss.
Naltrexone HCl Helps reduce cravings and reward driven eating.
Methylcobalamin (B12) Supports energy metabolism and neurological function.
Together, these ingredients support appetite control, craving reduction, mood balance, and improved metabolic patterns.
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📱 Digital Clinical Oversight — Simple, Fast, and Built Into Your Program
Every MetaVance Rx™ prescription includes digital clinical oversight to help you stay supported throughout your weight loss journey.
How It Works
• A secure, HIPAA compliant check in is sent directly to your phone
• Takes under 60 seconds to complete
• Tracks appetite, cravings, energy, mood, and weight loss progress
• Helps your provider stay informed and maintain ongoing oversight
This system keeps your care consistent and convenient — without weekly weigh ins or in person visits.
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📚 Clinical Evidence Overview
• Phentermine + Topiramate is FDA approved for chronic weight management and has shown 8–10% average weight loss over 56 weeks.
• Naltrexone + Bupropion is recommended by the American Gastroenterological Association as an adjunct to lifestyle changes, with 3–6% mean weight loss and improved emotional eating control.
• COR I and COR II trials show nearly 50% of patients on naltrexone/bupropion achieve ≥5% weight reduction.
• Methylcobalamin supports energy and neurological clarity, especially in patients with low B12.
• While the full five ingredient combination is not yet studied in a single trial, the multi pathway approach is clinically logical and used under provider supervision.
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🕒 How to Use
Take one sustained release capsule daily as directed by your provider.
MetaVance Rx™ is designed for gradual release to help you:
• Stay focused
• Feel full longer
• Reduce cravings
• Maintain steady progress throughout the day
Best used alongside nutrition, movement, and supportive habits.
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⚠️ Safety & Considerations
MetaVance Rx™ contains Phentermine, a Schedule IV controlled substance, along with additional active ingredients that require responsible prescribing and monitoring.
This medication will not be issued to patients who are:
• Pregnant
• Nursing
• Managing psychiatric conditions
• Currently taking opiate medications
• Planning to take opiates
• Taking MAO inhibitors
• Living with uncontrolled hypertension
• Living with cardiovascular disease
• Living with seizure disorders
Because MetaVance Rx™ contains Naltrexone, it is not appropriate for patients on opiate therapy.
Nightingale Rx™ offers several other weight management options that may be a better fit for individuals using opioid medications.
Common side effects may include dry mouth, insomnia, nausea, headache, or mood changes.
Your provider will review your medical history during your telehealth consultation to ensure this medication is safe and appropriate for you.
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💰 Pricing — Clear and All Inclusive
MetaVance Rx™ is compounded in a Florida 503A pharmacy.
Pricing reflects the complexity of the formulation and the clinical oversight included with every prescription.
30 Day Supply
$199
60 Day Supply
$349
90 Day Supply
$449
Included With Every Order
• Initial telemedicine consultation
• Ongoing clinical oversight, streamlined through digital check-in sent to your phone
• Lab coordination
No weigh in fees. No weekly clinic visits. No hidden charges.
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💬 MetaVance Rx™ by Nightingale Rx™
A multi pathway approach to appetite, cravings, mood, and metabolic support — all in one daily capsule.
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